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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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TiterMax.png

TiterMax®佐剂被用于增强免疫反应。TiterMax®佐剂有着跟弗氏佐剂相同的功效,但具有更安全、更易用的特点,是弗氏佐剂的理想代替产品。

 

TiterMax® adjuvants are used to produce cell mediated and humoral responses in research animals. TiterMax® adjuvants were developed to meet the specific needs of investigators for immunoadjuvants that are at least as effective as Freund's Complete Adjuvant, safer and easier to use. They are an attractive alternative to Freund's Complete Adjuvant for use by researchers in inducing antibody to diverse antigens. The key to the potency of TiterMax® adjuvants lies both in the immunostimulatory activity of their components and in the fact that they form a stable water-in-oil emulsion. TiterMax® adjuvants contain three essential ingredients: Proprietary block copolymers, squalene, a metabolizable oil, and a unique microparticulate stabilizer. Like Freund's Complete Adjuvant, TiterMax® adjuvants can be used with a wide variety of antigens because they can entrap any antigen in a water-in-oil emulsion. TiterMax® adjuvants aid in the antigens effective presentation to the immune system without the toxic effects of Freund's Complete Adjuvant.

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Axon Medchem.jpg

艾美捷科技特约代理Axon Medchem产品。


Axon Medchem的业务之一,是独有的Axon Ligands配体库,在世界范围内,被认为是药物研发的标准。这其中,针对850余种生物靶标(包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等),Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库,Axon Medchem还是欧洲著名的CRO公司,主要针对生物活性分子和药物类似分子展开合成及协议开发工作,在过去的10年中,Axon Medchem已经发现了多种潜在药物分子,并在生物医药界享有一定的声誉。

 

Axon Medchem is a trusted supplier of high-value life science products, providing Axon Ligands™ as world wide recognized drug reference standards for pharmacological research. With more than 2000 excellent quality small molecule inhibitors or modulators targeting more than 850 biological targets of cell signaling, gene transcription, apoptosis, cell cycle regulation, CNS and many more areas, Axon Medchem aims to facilitate your scientific research and development.  

 

Axon Medchem is also a leading European CRO in medicinal chemistry, specialized in contract research and high-quality synthesis of bio-active and/or drug-like molecules. We have the proven record in developing novel drug candidates and achieving excellence for a decade by providing our dedicated chemistry services for companies and research institutes active in the field of life sciences around the world.

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Neuro Probe.jpg

美国Neuro Probe公司专业提供用于趋化实验的耗材(Transwell),更好地服务于药筛和基础实验研究领域。着重开发研究细胞活性实验相关的耗材,从第一代用于趋化实验的Boyden Chamer(单孔小室)到48微孔板的趋化小室,再到今天的ChemTx System他们始终与科学实验的步伐保持一致,追求创新,不断地开发新产品以满足多样化的实验需求。

 

Neuro Probe was founded in the late 1960’s with an initial focus on the development and manufacture of chronic stereotactic equipment. In the early 1970’s, corporate growth and diversification lead to the development and production of chemotactic instruments, beginning with the modified Boyden chamber and then assorted blind well chambers. In 1980, the 48-well microchemotaxis chamber was developed, in collaboration with Dr. Edward Leonard and Dr. Werner Falk working at the National Institutes of Health. This chamber has become a standard in the field and has served as a basis for the development of many new products. Most recently introduced is the ChemoTx® system. Please visit the Products section of our website for more information on specific products.

 

Neuroprobe的主要产品包括:

ChemoTx®

Chemotaxis Chambers

Single Well Chambers

Filters

Replacement Gaskets

Chemotaxis Accessories

Protein Crystallography

Cell Settling Chambers

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