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Dendritics公司主要关注人类树突状细胞，希望找到能够促使CD34+造血前体细胞转化为树突状细胞（在GM-CSF和TNF-alpha存在的情况下）的细胞因子。在1992-2005年间，大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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艾美捷科技代理Trialtusbioscience品牌全系列产品

TriAltus Bioscience是一个致力于为推动人类健康前沿的科学家服务的品牌。当今的创新者在推进基因疗法、工程诊断、早期疾病检测以及药物发现等领域，都需要高纯度、高性能且随时可以扩展的酶，TriAltus正是为此而存在。TriAltus的核心是其专有的CLiM™（CL7/Im7）纯化平台，是一种基于亲和标签的突破性系统，能在单个色谱步骤中提供具有卓越纯度、活性和一致性的酶，重新定义了重组蛋白纯化的可能性。使用CLiM™生产的每种酶都以严格的质量控制、批次间一致性和详细的分析证书（COA）为后盾，旨在满足监管机构要求的质量和文档标准，支持从发现到扩大规模的更平稳过渡。TriAltus Bioscience公司的产品包括：基因组酶、蛋白酶和其他酶。

▍Trialtusbioscience产品线

● 基因组酶：TriAltus的重组基因组酶不含标签，并使用专有的CLiM™亲和标签系统进行纯化，提供目录酶的定制缩放和配方，以满足特定研究需求，无论需要更高的浓度、独特的缓冲条件还是批量生产，都可以根据具体规格定制酶。

货号	品名	规格	产品描述
40-1212	AapCas12b Protein	20 μg	expressed in E. coli and features two C-terminal nuclear localization signals，enables the inactive nuclease to be guided to the specific double stranded DNA site.
40-1220	AapCas12b Protein	100 μg
40-1225	AapCas12b Protein	500 μg
40-1320	CRISPR-Cas9 Protein	100 μg	used for genome editing with CRISPR technology. Recombinant Streptococcus pyogenes Cas9 ，expressed in Escherichia coli and features two nuclear localization signals
40-1325	CRISPR-Cas9 Protein	500 μg
40-2414	Phi29 DNA Polymerase	3,000 Units	a highly processive, isothermal enzyme from Bacillus subtilis phage phi29 ，with a robust 3'→5' proofreading exonuclease function.
40-2420	Phi29 DNA Polymerase	10,000 Units
40-2125	TAT-CRE Recombinase	500 μg	used for site-specific DNA recombination in mammalian cells,a fusion protein combining a nuclear localization sequence, HIV-TAT cell permeabilization peptide, and Cre recombinase.
40-2130	TAT-CRE Recombinase	1 mg
40-2135	TAT-CRE Recombinase	5 mg

● 蛋白酶和其他酶：例如为冷冻电镜生成蛋白质的实验室提供SUMO蛋白酶，去除相关标签后蛋白质可进行分析，反应高效、稳健，无需优化，客户对酶的性能和优质客户服务感到满意。

货号	品名	规格	产品描述
30-2130	PreScission Protease	1 mg	recognizes and cleaves the sequence LEVLFQ/GP to release the target protein from the Im7-bound CL7 tag
30-2135	PreScission Protease	5 mg
30-2140	PreScission Protease	10 mg
30-2146	PreScission Protease	50 mg
30-2150	PreScission Protease	100 mg
30-1130	SUMO Protease	1 mg	releases target proteins from TriAltus’s Im7 resin，recognizes SUMO tertiary structure – not a specific amino acid sequence – to cleave and release the target protein from the Im7-bound CL7 tag.
30-1135	SUMO Protease	5 mg
30-1140	SUMO Protease	10 mg
30-1146	SUMO Protease	50 mg
30-1150	SUMO Protease	100 mg